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Halichondrin B
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Halichondrin B is a large naturally occurring polyether macrolide originally isolated from the marine sponge ''Halichondria okadai'' by Hirata and Uemura in 1986. In the same report, these authors also reported the exquisite anticancer activity of halichondrin B against murine cancer cells both in culture and in ''in vivo'' studies. Halichondrin B was highly prioritized for development as a novel anticancer therapeutic by the United States National Cancer Institute〔(【引用サイトリンク】 Success Story: Halichondrin B (NSC 609395) E7389 (NSC 707389) )〕 and, in 1991, was the original test case for identification of mechanism of action (in this case, tubulin-targeted mitotic inhibitor) by NCI's then-brand-new "60-cell line screen"〔(【引用サイトリンク】 NCI-60 DTP Human Tumor Cell Line Screen )〕 The complete chemical synthesis of halichondrin B was achieved by Yoshito Kishi and colleagues at Harvard University in 1992, an achievement that ultimately enabled the discovery and development of the structurally simplified and pharmaceutically optimized analog eribulin (E7389, ER-086526, NSC-707389). Eribulin was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline- and taxane-based chemotherapies. Eribulin is marketed by Eisai Co. under the tradename Halaven.
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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